Dichloromethane → 7-(1-(Tert-butoxycarbonyl)piperidin-4-ylmethoxy)-4-(2-fluoro-4-methylanilino)-6-methoxyquinazoline
Reaction equation
[C:42]([CH3:43])([CH3:44])([CH3:45])[O:46][C:47](=[O:48])[N:49]1[CH2:50][CH2:51][CH:52]([CH2:55][OH:56])[CH2:53][CH2:54]1.[CH2:69]([Cl:70])[Cl:71].[F:20][c:21]1[c:22]([NH:23][c:24]2[n:25][cH:26][n:27][c:28]3[cH:29][c:30]([OH:36])[c:31]([O:34][CH3:35])[cH:32][c:33]23)[cH:37][cH:38][c:39]([CH3:41])[cH:40]1.[O:57]=[C:58]([O:59][CH2:60][CH3:61])[N:62]=[N:63][C:64]([O:65][CH2:66][CH3:67])=[O:68].[c:1]1([P:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:15][cH:16][cH:17][cH:18][cH:19]1>>[F:20][c:21]1[c:22]([NH:23][c:24]2[n:25][cH:26][n:27][c:28]3[cH:29][c:30]([O:36][CH2:55][CH:52]4[CH2:51][CH2:50][N:49]([C:47]([O:46][C:42]([CH3:43])([CH3:44])[CH3:45])=[O:48])[CH2:54][CH2:53]4)[c:31]([O:34][CH3:35])[cH:32][c:33]23)[cH:37][cH:38][c:39]([CH3:41])[cH:40]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-95d7a27a2d4041c4a82da5e3ae60384b
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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