Hydrochloric Acid → cis-N,N,4-trimethylpiperidine-3-carboxamide hydrochloride

HRID 931274Notes

Reaction equation

HRID 931274 reaction equation
[CH3:1][N:2]([CH3:19])[C:3]([C@H:5]1[C@@H:10]([CH3:11])[CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1)=[O:4].[ClH:20]>CCOCC>[ClH:20].[CH3:1][N:2]([CH3:19])[C:3]([C@H:5]1[C@@H:10]([CH3:11])[CH2:9][CH2:8][NH:7][CH2:6]1)=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131735161cis-Tert-butyl 3-(dimethylcarbamoyl)-4-methylpiperidine-1-carboxylate

Product 1

HCID 117966589cis-N,N,4-trimethylpiperidine-3-carboxamide hydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To cis-tert-butyl 3-(dimethylcarbamoyl)-4-methylpiperidine-1-carboxylate (0.3 g, 1.12 mmol) was added a solution of hydrogen chloride in ether. The mixture was stirred for 30 min, and then was concentrated under reduced pressure to afford cis-N,N,4-trimethylpiperidine-3-carboxamide hydrochloride (0.16 g) as a white solid. The material was used without further purification.

Workup

  1. concentrationwas concentrated under reduced pressure

Sources & evidence

ORD record
ord-378b8cbdea6b4728924d6a55259f2a33
Source dataset
uspto-grants-2016_03
Patent number
US09296745B2

Reaction notes

Loading…