Hydrochloric Acid → ethyl 1-(4-chloro-1H-pyrazol-1-yl)cyclopropanecarbimidate

HRID 931288Notes

Reaction equation

HRID 931288 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[N:5][N:6]([C:8]2([C:11]#[N:12])[CH2:10][CH2:9]2)[CH:7]=1.[CH2:13]([OH:15])[CH3:14]>>[Cl:2][C:3]1[CH:4]=[N:5][N:6]([C:8]2([C:11](=[NH:12])[O:15][CH2:13][CH3:14])[CH2:9][CH2:10]2)[CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 898536581-(4-Chloropyrazol-1-yl)cyclopropane-1-carbonitrile

Product 1

HCID 117966385ethyl 1-(4-chloro-1H-pyrazol-1-yl)cyclopropanecarbimidate

Procedure

Dry hydrogen chloride gas was bubbled through a solution of 1-(4-chloro-1H-pyrazol-1-yl)cyclopropanecarbonitrile (1.2 g, 0.75 mmol) in ethanol (10 mL) at 0° C. for 15 min. The mixture was then stirred at room temperature for 1 h. The solvent was removed under reduced pressure to afford ethyl 1-(4-chloro-1H-pyrazol-1-yl)cyclopropanecarbimidate. The crude material was used without further purification.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-16fc6807afbf451c8ef4285cfe087cef
Source dataset
uspto-grants-2016_03
Patent number
US09296745B2

Reaction notes

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