反应详情

A solution of hydrogen chloride in 1,4-dioxane (20 mL) was added to a solution of (R)-tert-butyl 2-(pyrrolidine-1-carbonyl)morpholine-4-carboxylate (0.62 g, 2.1 mmol) in \ 1,4-dioxane (5 mL). The reaction mixture was stirred at room temperature for 3 h. The solvent was removed under reduced pressure and the resulting crude material was triturated with diethyl ether to afford (R)-morpholin-2-yl(pyrrolidin-1-yl)methanone hydrochloride (0.4 g).

1. customThe solvent was removed under reduced pressure
2. customthe resulting crude material was triturated with diethyl ether