Hydrochloric Acid → (R)-morpholin-2-yl(pyrrolidin-1-yl)methanone hydrochloride

HRID 931317Notes

Reaction equation

HRID 931317 reaction equation
[ClH:1].[N:2]1([C:7]([C@@H:9]2[O:14][CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3]1>O1CCOCC1>[ClH:1].[NH:11]1[CH2:12][CH2:13][O:14][C@@H:9]([C:7]([N:2]2[CH2:6][CH2:5][CH2:4][CH2:3]2)=[O:8])[CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 117966471(R)-tert-butyl 2-(pyrrolidine-1-carbonyl)morpholine-4-carboxylate

Product 1

HCID 89853903(R)-morpholin-2-yl(pyrrolidin-1-yl)methanone hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of hydrogen chloride in 1,4-dioxane (20 mL) was added to a solution of (R)-tert-butyl 2-(pyrrolidine-1-carbonyl)morpholine-4-carboxylate (0.62 g, 2.1 mmol) in \ 1,4-dioxane (5 mL). The reaction mixture was stirred at room temperature for 3 h. The solvent was removed under reduced pressure and the resulting crude material was triturated with diethyl ether to afford (R)-morpholin-2-yl(pyrrolidin-1-yl)methanone hydrochloride (0.4 g).

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe resulting crude material was triturated with diethyl ether

Sources & evidence

ORD record
ord-777cb736477e4007a178d637ae411ac6
Source dataset
uspto-grants-2016_03
Patent number
US09296745B2

Reaction notes

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