反应详情

温度

23 °C

mCPBA (12.0 g, 69.3 mmol) was added portionwise over 5 min to a solution of 3-bromopyridin-2-amine (10 g, 58 mmol) in anhydrous acetone (150 mL) at 0° C. The resulting mixture was warmed to 23° C. and stirred for 1 h, then concentrated. The residue was partitioned between a solution of 5% methanol in chloroform and saturated aqueous sodium hydroxide solution (3×). The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, and concentrated to give the title compound. MS: m/z=189.0 (M+1).

1. concentrationconcentrated
2. customThe residue was partitioned between a solution of 5% methanol in chloroform and saturated aqueous sodium hydroxide solution (3×)
3. washThe combined organic layers were washed with brine
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated