反应详情

Reaction of benzoate 16 (290 mg, 0.78 mmol) and 6 M HCl (5 mL) gave acid 17 (278 mg, 100%) as a white solid: mp (H2O) 284-287° C.; 1H NMR δ 12.68 (br s, 1H, CO2H), 8.04 (br d, J=8.4 Hz, 2H, H-2, H-6), 7.90 (br d, J=8.4 Hz, 2H, H-3, H-5), 7.80 (br ddd, J=8.1, 1.9, 1.2 Hz, 2H, H-2′, H-6′), 7.75 (tt, J=7.5, 1.2 Hz, 1H, H-4′), 7.62 (br dd, J=8.1, 7.4 Hz, 2H, H-3′, H-5′), 4.68 (s, 2H, CH2SO2), 2.13 (s, 3H, CH3); MS m/z 358.8 (MH+, 100%).