HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 4-[4-(Hydroxymethyl)-5-methyl-1,3-oxazol-2-yl]benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 4-(4-(chloromethyl)-5-methyloxazol-2-yl)benzoate | HCID 23076573 | — |
| Product | 4-[4-(Hydroxymethyl)-5-methyl-1,3-oxazol-2-yl]benzoic acid | HCID 68278425 | 72% |
Reaction Steps
Reaction of chloride 2 (500 mg, 1.88 mmol) and aqueous NaOH (2 M, 10 mL, 20 mmol) gave acid 55 (313 mg, 72%) as a cream solid: mp (EtOAc/MeOH) 240-242° C.; 1H NMR δ □ 13.18 (br s, 1H, CO2H), 8.00-8.06 (m, 4H, H-2, H-3, H-5, H-6), 5.11 (br s, 1H, OH), 2.41 (s, 3H, CH3); MS m/z 234.5 (MH+, 100%); HRMS calcd for C12H12NO4: 234.0761. Found: 234.0760.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09296732B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-7c7e2eadb1e94dbfb764c3b4d32d7c6c |
| Source note | uspto-grants-2016_03 |