4-(Aminomethyl)-N-(3-pyridinyl)benzamide dihydrobromide → 4-(Aminomethyl)-N-(pyridin-3-YL)benzamide

HRID 931463Notes

Reaction equation

HRID 931463 reaction equation
Br.Br.[NH2:3][CH2:4][C:5]1[CH:19]=[CH:18][C:8]([C:9]([NH:11][C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[O:10])=[CH:7][CH:6]=1>N>[NH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([C:9]([NH:11][C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[O:10])=[CH:18][CH:19]=1

Participants

3

Reactant 1

HCID 706546444-(Aminomethyl)-N-(3-pyridinyl)benzamide dihydrobromide

Product 1

HCID 167745724-(Aminomethyl)-N-(pyridin-3-YL)benzamide

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Procedure

A suspension of dihydrobromide salt 32 (1 mmol) in dilute aqueous ammonia solution (50 mL) was extracted into CHCl3 (3×50 mL), the organic fraction dried and the solvent evaporated to give crude benzamide 33 which was used directly.

Workup

  1. extractionwas extracted into CHCl3 (3×50 mL)
  2. customthe organic fraction dried
  3. customthe solvent evaporated

Sources & evidence

ORD record
ord-6340222ef3b54806b37de5b0be5160d1
Source dataset
uspto-grants-2016_03
Patent number
US09296732B2

Reaction notes

Loading…