Hydrogen Sulfide → HCID 86709132, compound

HRID 931471Notes

Reaction equation

HRID 931471 reaction equation
[SH2:1].O=[C:3]1[CH2:8][CH2:7][N:6]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:5][CH2:4]1>C(O)(C)C>[S:1]=[C:3]1[CH2:8][CH2:7][N:6]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 402Hydrogen SulfideHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 86709132HCID 86709132, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Hydrogen sulfide gas was bubbled into a solution of tert-butyl 4-oxopiperidine-1-carboxylate (2 g, 10.05 mmol, 1.00 equiv) in isopropanol (20 mL) contained in a 100-mL 3-necked round-bottom flask. The resulting solution was stirred at room temperature for 2 h. The reaction mixture was concentrated and the crude product was used in the next step directly without purification.

Workup

  1. customcontained in a 100-mL 3-necked round-bottom flask
  2. concentrationThe reaction mixture was concentrated
  3. customthe crude product was used in the next step directly without purification

Sources & evidence

ORD record
ord-6578ac1c09be4d72ab147112365019e4
Source dataset
uspto-grants-2016_03
Patent number
US09296732B2

Reaction notes

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