Hydrochloric Acid → HCID 68277910, compound

HRID 931508Notes

Reaction equation

[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:16]=[CH:15][C:10]([C:11]([O:13]C)=[O:12])=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:17][S:18]([C:21]1[CH:26]=[CH:25][C:24]([CH2:27][CH2:28][N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)=[CH:23][CH:22]=1)(=[O:20])=[O:19].[ClH:35]>>[ClH:35].[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:16]=[CH:15][C:10]([C:11]([OH:13])=[O:12])=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:17][S:18]([C:21]1[CH:26]=[CH:25][C:24]([CH2:27][CH2:28][N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)=[CH:23][CH:22]=1)(=[O:19])=[O:20]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 68277987HCID 68277987, compound

Product 1

HCID 68277910HCID 68277910, compoundYield 96%

Procedure

A solution of methyl 4-(5-methyl-4-((4-(2-morpholinoethyl)phenylsulfonyl)methyl)oxazol-2-yl)benzoate (600 mg, 1.24 mmol, 1.00 equiv) in 6N hydrochloric acid (30 mL) was refluxed for 8 h. The reaction mixture was cooled to room temperature and concentrated under vacuum to give 0.6 g (96%) of 4-(5-methyl-4-((4-(2-morpholinoethyl)phenylsulfonyl)methyl)oxazol-2-yl)benzoic acid hydrochloride as a white solid.

Workup

concentrationconcentrated under vacuum

Sources & evidence

ORD record: ord-bf5eb066bce14cecbfa302173e1f451c
Source dataset: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09296732B2

Reaction notes

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