Ammonia → HCID 21828942, compound

HRID 931654Notes

Reaction equation

HRID 931654 reaction equation
[CH3:1][O:2][C:3]1[N:4]=[CH:5][C:6]([C:9]([O:11]C)=O)=[N:7][CH:8]=1.[NH3:13]>>[CH3:1][O:2][C:3]1[N:4]=[CH:5][C:6]([C:9]([NH2:13])=[O:11])=[N:7][CH:8]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 465070Methyl 5-methoxypyrazine-2-carboxylate

Product 1

HCID 21828942HCID 21828942, compound

Conditions

Temperature
50 °C

Procedure

To a 100-mL round-bottomed flask was added methyl 5-methoxypyrazine-2-carboxylate (0.811 g, 4.82 mmol, synthesized according to Journal of Heterocyclic Chemistry, 19(2), 407-8; 1982) and ammonia (2 M in MeOH; 25 mL, 50.0 mmol). The reaction mixture was heated to 50° C. overnight. The reaction mixture was allowed to cool to ambient temperature, filtered and dried to afford 5-methoxypyrazine-2-carboxamide as a white crystalline solid. MS m/z=154.0 [M+H]+. Calculated for C6H7N3O2: 153.14.

Workup

  1. temperatureto cool to ambient temperature
  2. filtrationfiltered
  3. customdried

Sources & evidence

ORD record
ord-297e2efc0d854ae99c505e99ec2c4009
Source dataset
uspto-grants-2016_03
Patent number
US09296759B2

Reaction notes

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