Ammonia → HCID 21828942, compound

Participants

Reaction Conditions

Reaction Steps

To a 100-mL round-bottomed flask was added methyl 5-methoxypyrazine-2-carboxylate (0.811 g, 4.82 mmol, synthesized according to Journal of Heterocyclic Chemistry, 19(2), 407-8; 1982) and ammonia (2 M in MeOH; 25 mL, 50.0 mmol). The reaction mixture was heated to 50° C. overnight. The reaction mixture was allowed to cool to ambient temperature, filtered and dried to afford 5-methoxypyrazine-2-carboxamide as a white crystalline solid. MS m/z=154.0 [M+H]+. Calculated for C6H7N3O2: 153.14.

Provenance & Evidence