5-(4-Chlorophenyl)-2,7-dimethyl-6-vinylquinoline → (S)-1-(5-(4-chlorophenyl)-2,7-dimethylquinolin-6-yl)ethane-1,2-diol

HRID 931711Notes

Reaction equation

HRID 931711 reaction equation
Cl[C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH3:12])=[N:9]2)=[C:4]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[C:3]=1[C@H:20]([OH:23])[CH2:21][OH:22].Cl[C:25]1C=CC(C2C(C=C)=C(C)C=C3C=2C=CC(C)=N3)=CC=1>>[Cl:19][C:16]1[CH:15]=[CH:14][C:13]([C:4]2[C:3]([C@H:20]([OH:23])[CH2:21][OH:22])=[C:2]([CH3:25])[CH:11]=[C:10]3[C:5]=2[CH:6]=[CH:7][C:8]([CH3:12])=[N:9]3)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 666317765-(4-Chlorophenyl)-2,7-dimethyl-6-vinylquinolineHCID 66633446(S)-1-(7-chloro-5-(4-chlorophenyl)-2-methylquinolin-6-yl)ethane-1,2-diol

Product 1

HCID 66633464(S)-1-(5-(4-chlorophenyl)-2,7-dimethylquinolin-6-yl)ethane-1,2-diol

Procedure

Compound 2G was prepared following the procedure used to prepare compound 1H of Example 1, except that 5-(4-chlorophenyl)-2,7-dimethyl-6-vinylquinoline (2F) was used instead of compound 1G. LCMS-ESI+ (m/z): 328.2, 330.2 (M+H)+.

Sources & evidence

ORD record
ord-316cad1d250d442ba4fb6de064a86422
Source dataset
uspto-grants-2016_03
Patent number
US09296758B2

Reaction notes

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