(S)-2-(5-bromo-2,7-dimethylquinolin-6-yl)-2-tert-butoxyethyl pivalate → (S)-2-(5-bromo-2,7-dimethylquinolin-6-yl)-2-tert-butoxyethanol

HRID 931730Notes

Reaction equation

HRID 931730 reaction equation
C(O[C@@H](C1C(C2C=CC(Cl)=CC=2)=C2C(=CC=1Cl)N=C(C)C=C2)CO)(C)(C)C.C([O:34][CH2:35][C@H:36]([C:42]1[C:43]([Br:54])=[C:44]2[C:49](=[CH:50][C:51]=1[CH3:52])[N:48]=[C:47]([CH3:53])[CH:46]=[CH:45]2)[O:37][C:38]([CH3:41])([CH3:40])[CH3:39])(=O)C(C)(C)C>>[Br:54][C:43]1[C:42]([C@H:36]([O:37][C:38]([CH3:39])([CH3:40])[CH3:41])[CH2:35][OH:34])=[C:51]([CH3:52])[CH:50]=[C:49]2[C:44]=1[CH:45]=[CH:46][C:47]([CH3:53])=[N:48]2

Participants

3

Reactant 2

HCID 66630692(S)-2-(5-bromo-2,7-dimethylquinolin-6-yl)-2-tert-butoxyethyl pivalateHCID 66631657(S)-2-tert-butoxy-2-(7-chloro-5-(4-chlorophenyl)-2-methylquinolin-6-yl)ethanol

Product 1

HCID 66631978(S)-2-(5-bromo-2,7-dimethylquinolin-6-yl)-2-tert-butoxyethanol

Procedure

Compound 5F was prepared following the procedure used to prepare compound 1K of Example 1, except that (S)-2-(5-bromo-2,7-dimethylquinolin-6-yl)-2-tert-butoxyethyl pivalate (5E) was used instead of compound 1J. LCMS-ESI+ (m/z): 352.2, 354.2 (M+H)+.

Sources & evidence

ORD record
ord-244efffbbc614a1c901de86dacb08646
Source dataset
uspto-grants-2016_03
Patent number
US09296758B2

Reaction notes

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