7-Chloro-2-methylquinolin-6-ol → 5-Bromo-7-methyl-2-(trifluoromethyl)quinolin-6-ol

HRID 931736Notes

Reaction equation

HRID 931736 reaction equation
ClC1C=C2C(C=CC(C)=N2)=CC=1O.[Br:14][C:15]1[C:24]([O:25]C)=[C:23]([CH3:27])[CH:22]=[C:21]2[C:16]=1[CH:17]=[CH:18][C:19]([C:28]([F:31])([F:30])[F:29])=[N:20]2>>[Br:14][C:15]1[C:24]([OH:25])=[C:23]([CH3:27])[CH:22]=[C:21]2[C:16]=1[CH:17]=[CH:18][C:19]([C:28]([F:29])([F:30])[F:31])=[N:20]2

Participants

3

Reactant 2

HCID 666314067-Chloro-2-methylquinolin-6-olHCID 666316895-Bromo-6-methoxy-7-methyl-2-(trifluoromethyl)quinoline

Product 1

HCID 666316125-Bromo-7-methyl-2-(trifluoromethyl)quinolin-6-ol

Procedure

Compound 7B was prepared following the procedure used to prepare compound 1C of Example 1, except that 5-bromo-6-methoxy-7-methyl-2-(trifluoromethyl)quinoline (7A) was used instead of compound 1B. LCMS-ESI+ (m/z): 306.1, 308.1 (M+H)+.

Sources & evidence

ORD record
ord-b9f9f67cd380429ea1068343a7ebe504
Source dataset
uspto-grants-2016_03
Patent number
US09296758B2

Reaction notes

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