HRID931756

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6329

Methylamine

CH5N

结构：Cc1cc2c(ccc(C)[n+]2[O-])c(-c2ccc(Cl)cc2)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C

HCID66631094

未命名化合物

结构：Cc1cc2nc(CN(C)C)ccc2c(Br)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C

HCID66631121

未命名化合物

PRODUCTS

生成物

结构：CNCc1ccc2c(-c3ccc(Cl)cc3)c([C@@H](COC(=O)C(C)(C)C)OC(C)(C)C)c(C)cc2n1

HCID66631400

未命名化合物

PROCEDURE

实验过程

Following the procedure used to prepare compound (S)-2-(5-bromo-2-((dimethylamino)methyl)-7-methylquinolin-6-yl)-2-tert-butoxyethyl pivalate of Example 9, except that (S)-6-(1-tert-butoxy-2-(pivaloyloxy)ethyl)-5-(4-chlorophenyl)-2,7-dimethylquinoline 1-oxide was used instead of (S)-5-bromo-6-(1-tert-butoxy-2-(pivaloyloxy)ethyl)-2,7-dimethylquinoline 1-oxide, and methylamine solution was used instead of N,N-dimethylamine solution. LCMS-ESI+ (m/z): 497.3, 499.3 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-150ccb98a7b1446f9b30a68acdb58c70
来源数据集: uspto-grants-2016_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09296758B2
来源说明: uspto-grants-2016_03

反应 SMILES

[C:1]([O:7][CH2:8][C@H:9]([C:15]1[C:16](Br)=[C:17]2[C:22](=[CH:23][C:24]=1[CH3:25])[N:21]=[C:20]([CH2:26][N:27]([CH3:29])C)[CH:19]=[CH:18]2)[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].C(O[C@@H](C1C([C:58]2[CH:63]=[CH:62][C:61]([Cl:64])=[CH:60][CH:59]=2)=C2C(=CC=1C)[N+]([O-])=C(C)C=C2)COC(=O)C(C)(C)C)(C)(C)C.CN>>[C:1]([O:7][CH2:8][C@@H:9]([O:10][C:11]([CH3:13])([CH3:14])[CH3:12])[C:15]1[C:16]([C:58]2[CH:63]=[CH:62][C:61]([Cl:64])=[CH:60][CH:59]=2)=[C:17]2[C:22](=[CH:23][C:24]=1[CH3:25])[N:21]=[C:20]([CH2:26][NH:27][CH3:29])[CH:19]=[CH:18]2)(=[O:6])[C:2]([CH3:3])([CH3:4])[CH3:5]