HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 931802Generated: October 30, 2026
Tetrahydrofuran → (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-2-hydrazinyl-7-methylquinolin-6-yl)ethyl pivalate
https://huagongshe.com/reaction/931802
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(trifluoromethylsulfonyloxy)quinolin-6-yl)ethyl pivalate | HCID 86691982 | — |
| Product | (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-2-hydrazinyl-7-methylquinolin-6-yl)ethyl pivalate | HCID 66632199 | — |
Reaction Steps
The mixture of (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methyl-2-(trifluoromethylsulfonyloxy)quinolin-6-yl)ethyl pivalate (compound of Example 26) (10 mg) and hydrazine in THF (1.0 N, 1 mL, 1 mmol) was heated at 80° C. for 12 hours. Concentration under reduced pressure gave (S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-2-hydrazinyl-7-methylquinolin-6-yl)ethyl pivalate, which was used for next step without purification. LCMS-ESI+ (m/z): [M+H]+ calcd for C27H35ClN3O3: 484.2. Found: 484.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09296758B2 |
|---|
| Source dataset | uspto-grants-2016_03 |
|---|
| ORD ID | ord-fbb71f3117414d9c8e9128f6ec75bc23 |
|---|
| Source note | uspto-grants-2016_03 |
|---|
