反应详情

温度

0 °C

16.6 g (57.1 mmol) of 8 are dissolved in 154 ml of tetrahydrofuran, cooled to 0° C., and a 1 M solution of tetra-n-butylammonium fluoride (68.48 mmol) is added dropwise. The batch is stirred at room temperature overnight, water is added, the mixture is extracted with methyl t-butyl ether, the organic phase is dried over sodium sulfate and filtered, the solvent is removed in vacuo, and the residue is filtered through silica gel with heptane/toluene, giving the product 9, which is employed in the next step without further purification.

1. extractionthe mixture is extracted with methyl t-butyl ether
2. dry with materialthe organic phase is dried over sodium sulfate
3. filtrationfiltered
4. customthe solvent is removed in vacuo
5. filtrationthe residue is filtered through silica gel with heptane/toluene