Trifluoroacetic acid → 1-(5-Methylpyrazin-2-yl)-4,4'-bipiperidine

HRID 932372Notes

Reaction equation

HRID 932372 reaction equation
[CH3:1][c:2]1[n:3][cH:4][c:5]([N:8]2[CH2:9][CH2:10][CH:11]([CH:14]3[CH2:15][CH2:16][N:17]([C:20]([O:21][C:22]([CH3:23])([CH3:24])[CH3:25])=[O:26])[CH2:18][CH2:19]3)[CH2:12][CH2:13]2)[n:6][cH:7]1.[OH:27][C:28]([C:29]([F:30])([F:31])[F:32])=[O:33]>>[CH3:1][c:2]1[n:3][cH:4][c:5]([N:8]2[CH2:9][CH2:10][CH:11]([CH:14]3[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]3)[CH2:12][CH2:13]2)[n:6][cH:7]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59178865Tert-butyl 1'-(5-methylpyrazin-2-yl)-4,4'-bipiperidine-1-carboxylate

Product 1

HCID 591788971-(5-Methylpyrazin-2-yl)-4,4'-bipiperidine

Sources & evidence

ORD record
ord-8d2f5f7facab4015aeb1e8526f0112ce
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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