Potassium Cation → 7-(Benzyloxy)-4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazoline

HRID 932380Notes

Reaction equation

HRID 932380 reaction equation
[C:34](=[O:35])([O-:36])[O-:37].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[c:10]([O:20][CH3:21])[cH:11][c:12]2[c:13]([Cl:19])[n:14][cH:15][n:16][c:17]2[cH:18]1.[CH3:40][N:41]1[CH2:42][CH2:43][CH2:44][C:45]1=[O:46].[F:22][c:23]1[c:24]2[cH:25][c:26]([CH3:33])[nH:27][c:28]2[cH:29][cH:30][c:31]1[OH:32].[K+:38].[K+:39]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[c:10]([O:20][CH3:21])[cH:11][c:12]2[c:13]([O:32][c:31]3[c:23]([F:22])[c:24]4[cH:25][c:26]([CH3:33])[nH:27][c:28]4[cH:29][cH:30]3)[n:14][cH:15][n:16][c:17]2[cH:18]1

Participants

6

Reactant 5

HCID 813Potassium Cation2×HCID 13387N-methyl-2-pyrrolidoneHCID 19660Carbonate IonHCID 103520364-fluoro-2-methyl-1H-indol-5-olHCID 106619987-(Benzyloxy)-4-chloro-6-methoxyquinazoline

Product 1

HCID 101512047-(Benzyloxy)-4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazoline

Sources & evidence

ORD record
ord-36423528756c4c04b9c1d4b8c1778abf
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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