Potassium Cation → Methyl 3-bromo-5-[2-(4-chlorophenyl)-2'-oxospiro[cyclopropane-1,3'-indole]-1'-yl]benzoate
Reaction equation
[CH3:26][NH:27][CH2:28][CH2:29][NH:30][CH3:31].[CH3:32][O:33][C:34]([c:35]1[cH:36][c:37]([Br:42])[cH:38][c:39]([I:41])[cH:40]1)=[O:43].[CH3:46][C:47]#[N:48].[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[C:9]3([CH2:10]2)[C:11](=[O:19])[NH:12][c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]23)[cH:6][cH:7]1.[Cu:44][I:45].[K+:20].[K+:21].[O-:22][C:23]([O-:24])=[O:25]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[C:9]3([CH2:10]2)[C:11](=[O:19])[N:12]([c:39]2[cH:38][c:37]([Br:42])[cH:36][c:35]([C:34]([O:33][CH3:32])=[O:43])[cH:40]2)[c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]23)[cH:6][cH:7]1Participants
8
Reactant 7
HCID 813Potassium Cation2×
HCID 6342Acetonitrile
HCID 8070N,N'-Dimethylethylenediamine
HCID 19660Carbonate Ion
HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)
HCID 21942573Methyl 3-bromo-5-iodobenzoate
HCID 672320902-(4-Chlorophenyl)spiro[cyclopropane-1,3'-indolin]-2'-oneProduct 1
Sources & evidence
- ORD record
- ord-5c11df706ff848c5bec3577c66f5951a
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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