Water → 2-(4'-Bromo-3'-fluorophenyl)-5-(trans-4'-propylcyclohexyl)-1,3-dioxane

HRID 932729Notes

Reaction equation

HRID 932729 reaction equation
[Br:15][c:16]1[c:17]([F:24])[cH:18][c:19]([CH:20]=[O:21])[cH:22][cH:23]1.[CH2:1]([CH2:2][CH3:3])[CH:4]1[CH2:5][CH2:6][CH:7]([CH:10]([CH2:11][OH:12])[CH2:13][OH:14])[CH2:8][CH2:9]1.[CH3:25][c:26]1[cH:27][cH:28][c:29]([S:30]([OH:31])(=[O:32])=[O:33])[cH:34][cH:35]1.[Cl:37][CH2:38][Cl:39].[OH2:36]>>[CH2:1]([CH2:2][CH3:3])[CH:4]1[CH2:5][CH2:6][CH:7]([CH:10]2[CH2:11][O:12][CH:20]([c:19]3[cH:18][c:17]([F:24])[c:16]([Br:15])[cH:23][cH:22]3)[O:14][CH2:13]2)[CH2:8][CH2:9]1

Participants

6

Reactant 5

HCID 962WaterHCID 6101p-Toluenesulfonic acidHCID 6344DichloromethaneHCID 27834114-Bromo-3-fluorobenzaldehydeHCID 112294182-(4-Propylcyclohexyl)propane-1,3-diol

Product 1

HCID 197387252-(4'-Bromo-3'-fluorophenyl)-5-(trans-4'-propylcyclohexyl)-1,3-dioxane

Sources & evidence

ORD record
ord-e84efb936a1a4a44966d945aeeda28dc
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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