Hydrochloric Acid → 4-(2-Fluoro-5-hydroxy-4-methylanilino)-7-hydroxyquinazoline

HRID 932735Notes

Reaction equation

HRID 932735 reaction equation
[CH3:29][OH:30].[ClH:3].[F:4][c:5]1[c:6]([NH:7][c:8]2[n:9][cH:10][n:11][c:12]3[cH:13][c:14]([OH:18])[cH:15][cH:16][c:17]23)[cH:19][c:20]([O:24][C:25]([O:26][CH3:27])=[O:28])[c:21]([CH3:23])[cH:22]1.[Na+:2].[OH-:1]>>[F:4][c:5]1[c:6]([NH:7][c:8]2[n:9][cH:10][n:11][c:12]3[cH:13][c:14]([OH:18])[cH:15][cH:16][c:17]23)[cH:19][c:20]([OH:24])[c:21]([CH3:23])[cH:22]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 135671178[4-Fluoro-5-[(7-hydroxyquinazolin-4-yl)amino]-2-methylphenyl] methyl carbonate

Product 1

HCID 1355493894-(2-Fluoro-5-hydroxy-4-methylanilino)-7-hydroxyquinazoline

Sources & evidence

ORD record
ord-dfeb2e197e3b4c499b000bbb2eb4e530
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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