Hydrochloric Acid → 6,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-3-carbonitrile

HRID 933008Notes

Reaction equation

HRID 933008 reaction equation
[CH3:39][CH2:40][O:41][CH2:42][CH2:43][OH:44].[Cl:1][c:2]1[c:3]([C:16]#[N:17])[cH:4][n:5][c:6]2[cH:7][c:8]([O:14][CH3:15])[c:9]([O:12][CH3:13])[cH:10][c:11]12.[ClH:18].[O:25]([c:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1)[c:32]1[cH:33][cH:34][c:35]([NH2:36])[cH:37][cH:38]1.[n:19]1[cH:20][cH:21][cH:22][cH:23][cH:24]1>>[c:2]1([NH:36][c:35]2[cH:34][cH:33][c:32]([O:25][c:26]3[cH:27][cH:28][cH:29][cH:30][cH:31]3)[cH:38][cH:37]2)[c:3]([C:16]#[N:17])[cH:4][n:5][c:6]2[cH:7][c:8]([O:14][CH3:15])[c:9]([O:12][CH3:13])[cH:10][c:11]12

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 8076Glycol monoethyl etherHCID 8764(4-Aminophenoxy)benzeneHCID 105866764-Chloro-6,7-dimethoxy-quinoline-3-carbonitrile

Product 1

HCID 99781256,7-Dimethoxy-4-(4-phenoxy-phenylamino)-quinoline-3-carbonitrile

Sources & evidence

ORD record
ord-c3a2200000ab43d3bb1b23ddc4ab0f80
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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