Chloroform → 6-Bromo-4-chloro-2-(2-fluorophenyl)quinazoline

HRID 933055Notes

Reaction equation

HRID 933055 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5](=[O:19])[nH:6][c:7](-[c:12]3[c:13]([F:18])[cH:14][cH:15][cH:16][cH:17]3)[n:8][c:9]2[cH:10][cH:11]1.[CH:24]([N:25]([CH3:26])[CH3:27])=[O:28].[CH:29]([Cl:30])([Cl:31])[Cl:32].[S:20]([Cl:21])([Cl:22])=[O:23]>>[Br:1][c:2]1[cH:3][c:4]2[c:5]([Cl:22])[n:6][c:7](-[c:12]3[c:13]([F:18])[cH:14][cH:15][cH:16][cH:17]3)[n:8][c:9]2[cH:10][cH:11]1

Participants

5

Reactant 4

HCID 6212ChloroformHCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 1358430616-Bromo-2-(2-fluoro-phenyl)-3H-quinazolin-4-one

Product 1

HCID 184406506-Bromo-4-chloro-2-(2-fluorophenyl)quinazoline

Sources & evidence

ORD record
ord-a698bbd0cc244596a6c7c2cffaa588b7
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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