Toluene → trans-4-Thiocarbamoyl-cyclohexanecarboxylic acid methyl ester

HRID 933377Notes

Reaction equation

HRID 933377 reaction equation
[CH3:14][O:15][c:16]1[cH:17][cH:18][c:19]([P:20]2(=[S:23])[S:21][P:22]([c:24]3[cH:25][cH:26][c:27]([O:28][CH3:29])[cH:30][cH:31]3)(=[S:32])[S:33]2)[cH:34][cH:35]1.[CH3:1][O:2][C:3](=[O:4])[CH:5]1[CH2:6][CH2:7][CH:8]([C:11]([NH2:12])=[O:13])[CH2:9][CH2:10]1.[CH3:41][c:42]1[cH:43][cH:44][cH:45][cH:46][cH:47]1.[O:36]1[CH2:37][CH2:38][CH2:39][CH2:40]1>>[CH3:1][O:2][C:3](=[O:4])[CH:5]1[CH2:6][CH2:7][CH:8]([C:11]([NH2:12])=[S:23])[CH2:9][CH2:10]1

Participants

5

Reactant 4

HCID 1140TolueneHCID 8028TetrahydrofuranHCID 87949Lawesson's reagentHCID 15105949Methyl 4-carbamoylcyclohexanecarboxylate

Product 1

HCID 57516982trans-4-Thiocarbamoyl-cyclohexanecarboxylic acid methyl ester

Sources & evidence

ORD record
ord-2177054b112d42618a024a357af8fce0
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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