Potassium Cation → 4-(4-Bromobenzyl)piperazine, N1-BOC protected

HRID 933531Notes

Reaction equation

HRID 933531 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([CH2:8][Br:9])[cH:6][cH:7]1.[K+:23].[K+:24].[N:10]1([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]1.[O-:25][C:26]([O-:27])=[O:28].[O:29]=[CH:30][N:31]([CH3:32])[CH3:33]>>[Br:1][c:2]1[cH:3][cH:4][c:5]([CH2:8][N:13]2[CH2:12][CH2:11][N:10]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:15][CH2:14]2)[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 813Potassium Cation2×HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 685274-Bromobenzyl bromideHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 27955194-(4-Bromobenzyl)piperazine, N1-BOC protected

Sources & evidence

ORD record
ord-6299fe695a5b462288ccb682b065f797
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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