2-Chloro-4-(2-(trimethylsilyl)ethynyl)pyridine → 2-Chloro-4-[2-methyl-1-(2,2,2-trifluoro-ethyl)-1H-imidazol-4-ylethynyl]-pyridine
Reaction equation
[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([C:8]#[C:9][Si:10]([CH3:11])([CH3:12])[CH3:13])[cH:7]1.[I:14][c:15]1[n:16][c:17]([CH3:25])[n:18]([CH2:20][C:21]([F:22])([F:23])[F:24])[cH:19]1>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([C:8]#[C:9][c:15]2[n:16][c:17]([CH3:25])[n:18]([CH2:20][C:21]([F:22])([F:23])[F:24])[cH:19]2)[cH:7]1Participants
3
Sources & evidence
- ORD record
- ord-4ffc21e3b1db4e9ab4a19ec132a15dbd
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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