Dichloromethane → 8-Phenyl-4-thiophen-3-yl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 933939Notes

Reaction equation

HRID 933939 reaction equation
[C:1]([O:2][C:3](=[O:4])[NH:7][c:8]1[c:9]([NH:20][C:21]([CH2:22][C:23](=[O:5])[c:24]2[cH:25][s:26][cH:27][cH:28]2)=[O:30])[cH:10][c:11](-[c:14]2[cH:15][cH:16][cH:17][cH:18][cH:19]2)[cH:12][cH:13]1)([CH3:6])([CH3:29])[CH3:31].[Cl:39][CH2:40][Cl:41].[F:32][C:33]([F:34])([F:35])[C:36]([OH:37])=[O:38]>>[N:7]1=[C:23]([c:24]2[cH:25][s:26][cH:27][cH:28]2)[CH2:22][C:21](=[O:30])[NH:20][c:9]2[c:8]1[cH:13][cH:12][c:11](-[c:14]1[cH:15][cH:16][cH:17][cH:18][cH:19]1)[cH:10]2

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 86588003[3-(3-Oxo-3-thiophen-3-yl-propionylamino)-biphenyl-4-yl]-carbamic acid tert.-butyl ester

Product 1

HCID 222247958-Phenyl-4-thiophen-3-yl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

Sources & evidence

ORD record
ord-2f3f370ba26e43b1a0aefaa17729fb8f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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