Dichloromethane → 4-[(7-amino-5,6,7,8-tetrahydronaphthalen-2-yl)oxy]-N,N-dimethylbutanamide

HRID 934023Notes

Reaction equation

[C:1]([O:2][C:3](=[O:4])[NH:8][CH:9]1[CH2:10][c:11]2[cH:12][c:13]([O:19][CH2:20][CH2:21][CH2:22][C:23](=[O:24])[N:25]([CH3:26])[CH3:27])[cH:14][cH:15][c:16]2[CH2:17][CH2:18]1)([CH3:5])([CH3:6])[CH3:7].[CH2:35]([Cl:36])[Cl:37].[OH:28][C:29]([C:30]([F:31])([F:32])[F:33])=[O:34]>>[NH2:8][CH:9]1[CH2:10][c:11]2[cH:12][c:13]([O:19][CH2:20][CH2:21][CH2:22][C:23](=[O:24])[N:25]([CH3:26])[CH3:27])[cH:14][cH:15][c:16]2[CH2:17][CH2:18]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 23287808tert-butyl N-[7-[4-(dimethylamino)-4-oxobutoxy]-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate

Product 1

HCID 232878194-[(7-amino-5,6,7,8-tetrahydronaphthalen-2-yl)oxy]-N,N-dimethylbutanamide

Sources & evidence

ORD record: ord-a1ffaaa58f634c92b8e0aaca870d9fd0
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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