Dimethylformamide → 1-O-tert-butyl 2-O-methyl 4-[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypyrrolidine-1,2-dicarboxylate

HRID 934031Notes

Reaction equation

[CH3:54][N:55]([CH3:56])[CH:57]=[O:58].[Cl:1][c:2]1[c:3]([F:22])[c:4]([NH:5][c:6]2[n:7][cH:8][n:9][c:10]3[cH:11][c:12]([O:17][CH3:18])[c:13]([OH:16])[cH:14][c:15]23)[cH:19][cH:20][cH:21]1.[Cs+:53].[F-:52].[N+:23]([c:24]1[cH:25][cH:26][c:27]([S:28]([O:29][CH:36]2[CH2:37][CH:38]([C:48](=[O:49])[O:50][CH3:51])[N:39]([C:41](=[O:42])[O:43][C:44]([CH3:45])([CH3:46])[CH3:47])[CH2:40]2)(=[O:30])=[O:31])[cH:32][cH:33]1)([O-:34])=[O:35]>>[Cl:1][c:2]1[c:3]([F:22])[c:4]([NH:5][c:6]2[n:7][cH:8][n:9][c:10]3[cH:11][c:12]([O:17][CH3:18])[c:13]([O:16][CH:36]4[CH2:37][CH:38]([C:48](=[O:49])[O:50][CH3:51])[N:39]([C:41](=[O:42])[O:43][C:44]([CH3:45])([CH3:46])[CH3:47])[CH2:40]4)[cH:14][c:15]23)[cH:19][cH:20][cH:21]1