Dichloromethane → N-[3-(2-amino-4,4a,5,6-tetrahydrofuro[2,3-d][1,3]thiazin-7a-yl)-4-fluorophenyl]-5-cyanopyridine-2-carboxamide

HRID 934109Notes

Reaction equation

[C:1](#[N:2])[c:3]1[cH:4][cH:5][c:6]([C:9](=[O:10])[NH:11][c:12]2[cH:13][cH:14][c:15]([F:35])[c:16]([C:18]34[N:19]=[C:20]([NH:27][C:28](=[O:29])[O:30][C:31]([CH3:32])([CH3:33])[CH3:34])[S:21][CH2:22][CH:23]3[CH2:24][CH2:25][O:26]4)[cH:17]2)[n:7][cH:8]1.[Cl:43][CH2:44][Cl:45].[F:36][C:37]([F:38])([F:39])[C:40]([OH:41])=[O:42]>>[C:1](#[N:2])[c:3]1[cH:4][cH:5][c:6]([C:9](=[O:10])[NH:11][c:12]2[cH:13][cH:14][c:15]([F:35])[c:16]([C:18]34[N:19]=[C:20]([NH2:27])[S:21][CH2:22][CH:23]3[CH2:24][CH2:25][O:26]4)[cH:17]2)[n:7][cH:8]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 123399491tert-butyl N-[7a-[5-[(5-cyanopyridine-2-carbonyl)amino]-2-fluorophenyl]-4,4a,5,6-tetrahydrofuro[2,3-d][1,3]thiazin-2-yl]carbamate

Product 1

HCID 123862168N-[3-(2-amino-4,4a,5,6-tetrahydrofuro[2,3-d][1,3]thiazin-7a-yl)-4-fluorophenyl]-5-cyanopyridine-2-carboxamide

Sources & evidence

ORD record: ord-23c9b392bf83465c8199063251a41b90
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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