Sodium ion → (3RS)-2,3-dihydro-1-(isoquinolin-1-yl)methyl-5-phenyl-3-phthalimido-1H-1,4-benzodiazepin-2-one

HRID 934142Notes

Reaction equation

HRID 934142 reaction equation
[CH3:46][N:47]([CH3:48])[CH:49]=[O:50].[Cl:34][CH2:35][c:36]1[n:37][cH:38][cH:39][c:40]2[cH:41][cH:42][cH:43][cH:44][c:45]12.[H-:1].[I-:33].[Na+:2].[Na+:32].[c:3]1([C:9]2=[N:10][CH:11]([N:21]3[C:22](=[O:31])[c:23]4[c:24]([cH:27][cH:28][cH:29][cH:30]4)[C:25]3=[O:26])[C:12](=[O:20])[NH:13][c:14]3[c:15]2[cH:16][cH:17][cH:18][cH:19]3)[cH:4][cH:5][cH:6][cH:7][cH:8]1>>[c:3]1([C:9]2=[N:10][CH:11]([N:21]3[C:22](=[O:31])[c:23]4[c:24]([cH:27][cH:28][cH:29][cH:30]4)[C:25]3=[O:26])[C:12](=[O:20])[N:13]([CH2:35][c:36]3[n:37][cH:38][cH:39][c:40]4[cH:41][cH:42][cH:43][cH:44][c:45]34)[c:14]3[c:15]2[cH:16][cH:17][cH:18][cH:19]3)[cH:4][cH:5][cH:6][cH:7][cH:8]1

Participants

7

Reactant 6

HCID 923Sodium ion2×HCID 6228DimethylformamideHCID 30165Iodide IonHCID 166653HydrideHCID 132210311-(Chloromethyl)isoquinolineHCID 14800302(3RS)-1,3-dihydro-5-phenyl-3-phthalimido-2H-1,4-benzodiazepine-2-one

Product 1

HCID 19081216(3RS)-2,3-dihydro-1-(isoquinolin-1-yl)methyl-5-phenyl-3-phthalimido-1H-1,4-benzodiazepin-2-one

Sources & evidence

ORD record
ord-95f59fac06fd432394271f9900e8d572
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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