Methanol → 4-amino-N-(1-(4-chlorophenyl)-4-hydroxybutyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide

HRID 934182Notes

Reaction equation

[CH3:46][OH:47].[Cl:8][c:9]1[cH:10][cH:11][c:12]([CH:15]([CH2:16][CH2:17][CH2:18][OH:19])[NH:20][C:21](=[O:22])[C:23]2([NH:38][C:39](=[O:40])[O:41][C:42]([CH3:43])([CH3:44])[CH3:45])[CH2:24][CH2:25][N:26]([c:29]3[c:30]4[c:31]([n:32][cH:33][n:34]3)[nH:35][cH:36][cH:37]4)[CH2:27][CH2:28]2)[cH:13][cH:14]1.[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[Cl:8][c:9]1[cH:10][cH:11][c:12]([CH:15]([CH2:16][CH2:17][CH2:18][OH:19])[NH:20][C:21](=[O:22])[C:23]2([NH2:38])[CH2:24][CH2:25][N:26]([c:29]3[c:30]4[c:31]([n:32][cH:33][n:34]3)[nH:35][cH:36][cH:37]4)[CH2:27][CH2:28]2)[cH:13][cH:14]1

Participants

Reactant 3

HCID 887Methanol

HCID 6422Trifluoroacetic acid

HCID 57750349tert-butyl 4-(1-(4-chlorophenyl)-4-hydroxybutylcarbamoyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-ylcarbamate

Product 1

HCID 426021754-amino-N-(1-(4-chlorophenyl)-4-hydroxybutyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide

Sources & evidence

ORD record: ord-f130cf9475fa437aa5302d038f48f49a
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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