N-methyl-2-pyrrolidone → 5-(2-(4-(1H-Benzo[D]imidazole-2-carbonyl)phenoxy)pyridin-3-YL)-1-methylazepan-2-one

HRID 934228Notes

Reaction equation

HRID 934228 reaction equation
[C:1](=[O:2])([O-:3])[O-:4].[CH3:41][N:42]1[CH2:43][CH2:44][CH2:45][C:46]1=[O:47].[Cs+:5].[Cs+:6].[F:25][c:26]1[n:27][cH:28][cH:29][cH:30][c:31]1[CH:32]1[CH2:33][CH2:34][C:35](=[O:40])[N:36]([CH3:39])[CH2:37][CH2:38]1.[nH:7]1[c:8]([C:16](=[O:17])[c:18]2[cH:19][cH:20][c:21]([OH:24])[cH:22][cH:23]2)[n:9][c:10]2[c:11]1[cH:12][cH:13][cH:14][cH:15]2>>[nH:7]1[c:8]([C:16](=[O:17])[c:18]2[cH:19][cH:20][c:21]([O:24][c:26]3[n:27][cH:28][cH:29][cH:30][c:31]3[CH:32]3[CH2:33][CH2:34][C:35](=[O:40])[N:36]([CH3:39])[CH2:37][CH2:38]3)[cH:22][cH:23]2)[n:9][c:10]2[c:11]1[cH:12][cH:13][cH:14][cH:15]2

Participants

6

Reactant 5

HCID 13387N-methyl-2-pyrrolidoneHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 59326874(1H-benzo[d]imidazol-2-yl)(4-hydroxyphenyl)methanoneHCID 593270605-(2-Fluoropyridin-3-yl)-1-methylazepan-2-one

Product 1

HCID 462147165-(2-(4-(1H-Benzo[D]imidazole-2-carbonyl)phenoxy)pyridin-3-YL)-1-methylazepan-2-one

Sources & evidence

ORD record
ord-2c7f8e16b76e41c584ba0872ab98be24
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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