Ethanol → Carbamic acid, [(1S)-2-(3,5-difluorophenyl)-1-(2R)-oxiranylethyl]-,1,1-dimethylethyl ester

HRID 934229Notes

Reaction equation

HRID 934229 reaction equation
[Br:1][CH2:2][CH:3]([CH:4]([CH2:5][c:6]1[cH:7][c:8]([F:13])[cH:9][c:10]([F:12])[cH:11]1)[NH:14][C:15]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:21])[OH:22].[CH2:31]([OH:32])[CH3:33].[CH3:23][CH2:24][O:25][C:26](=[O:27])[CH3:28].[K+:30].[OH-:29]>>[CH2:2]1[CH:3]([CH:4]([CH2:5][c:6]2[cH:7][c:8]([F:13])[cH:9][c:10]([F:12])[cH:11]2)[NH:14][C:15]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:21])[O:22]1

Participants

6

Reactant 5

HCID 702EthanolHCID 813Potassium CationHCID 961HydroxideHCID 8857Ethyl AcetateHCID 178453314HCID 178453314, compound

Product 1

HCID 20726936Carbamic acid, [(1S)-2-(3,5-difluorophenyl)-1-(2R)-oxiranylethyl]-,1,1-dimethylethyl ester

Sources & evidence

ORD record
ord-51c39cc67eac4220bbfc2f4b6ab8daf8
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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