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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 934276Generated: October 26, 2026

1,2-Dichloroethane → (RS)-1-[2-(4,5-Difluoro-1H-benzoimidazol-2-ylmethyl)-piperidin-1-yl]-1-[5-(4-fluoro-phenyl)-2-hydroxymethyl-thiazol-4-yl]-methanone

https://huagongshe.com/reaction/934276

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,2-DichloroethaneHCID 11—
ReactantHydrochloric AcidHCID 313—
ReactantMethanolHCID 887—
ReactantDiethyl EtherHCID 3283—
ReactantDimethylformamideHCID 6228—
ReactantDichloromethaneHCID 6344—
Reactant1-HydroxybenzotriazoleHCID 75771—
Reactant(RS)-4,5-Difluoro-2-piperidin-2-ylmethyl-1H-benzoimidazoleHCID 17973676—
Reactant5-(4-Fluoro-phenyl)-2-hydroxymethyl-thiazole-4-carboxylic acidHCID 23450138—
Product(RS)-1-[2-(4,5-Difluoro-1H-benzoimidazol-2-ylmethyl)-piperidin-1-yl]-1-[5-(4-fluoro-phenyl)-2-hydroxymethyl-thiazol-4-yl]-methanoneHCID 66968516—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetValidation data from https://doi.org/10.1039/C8SC04228D
ORD IDord-317baefee5af4fa09b40dd5be1ac04ee
Source noteValidation data from https://doi.org/10.1039/C8SC04228D