1,2-Dichloroethane → (RS)-1-[2-(4,5-Difluoro-1H-benzoimidazol-2-ylmethyl)-piperidin-1-yl]-1-[5-(4-fluoro-phenyl)-2-hydroxymethyl-thiazol-4-yl]-methanone
Reaction equation
[CH2:36]([Cl:37])[CH2:38][Cl:39].[CH3:56][CH2:57][O:58][CH2:59][CH3:60].[CH3:64][OH:65].[Cl:61][CH2:62][Cl:63].[ClH:40].[F:18][c:19]1[c:20]([F:35])[cH:21][cH:22][c:23]2[nH:24][c:25]([CH2:28][CH:29]3[NH:30][CH2:31][CH2:32][CH2:33][CH2:34]3)[n:26][c:27]12.[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9]([C:15](=[O:16])[OH:17])[n:10][c:11]([CH2:13][OH:14])[s:12]2)[cH:6][cH:7]1.[O:51]=[CH:52][N:53]([CH3:54])[CH3:55].[OH:41][n:42]1[c:43]2[cH:44][cH:45][cH:46][cH:47][c:48]2[n:49][n:50]1>>[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9]([C:15](=[O:17])[N:30]3[CH:29]([CH2:28][c:25]4[nH:24][c:23]5[cH:22][cH:21][c:20]([F:35])[c:19]([F:18])[c:27]5[n:26]4)[CH2:34][CH2:33][CH2:32][CH2:31]3)[n:10][c:11]([CH2:13][OH:14])[s:12]2)[cH:6][cH:7]1Participants
10
Reactant 9
Product 1
Sources & evidence
- ORD record
- ord-317baefee5af4fa09b40dd5be1ac04ee
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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