Diethyl (ethoxymethylene)malonate → diethyl [N-cyclopropyl-N-[3-(4-ethoxycarbonyl-1-piperazinyl)-2-methyl-4-fluoro-6-nitrophenyl]aminomethylene]malonate
Reaction equation
[CH2:27]([O:28][CH:30]=[C:31]([C:32](=[O:33])[O:34][CH2:35][CH3:36])[C:37](=[O:38])[O:39][CH2:40][CH3:41])[CH3:29].[CH:1]1([NH:4][c:5]2[c:6]([CH3:26])[c:7]([N:15]3[CH2:16][CH2:17][N:18]([C:21](=[O:22])[O:23][CH2:24][CH3:25])[CH2:19][CH2:20]3)[c:8]([F:14])[cH:9][c:10]2[N+:11](=[O:12])[O-:13])[CH2:2][CH2:3]1>>[CH:1]1([N:4]([c:5]2[c:6]([CH3:26])[c:7]([N:15]3[CH2:16][CH2:17][N:18]([C:21](=[O:22])[O:23][CH2:24][CH3:25])[CH2:19][CH2:20]3)[c:8]([F:14])[cH:9][c:10]2[N+:11](=[O:12])[O-:13])[CH:30]=[C:31]([C:32](=[O:33])[O:34][CH2:35][CH3:36])[C:37](=[O:38])[O:39][CH2:40][CH3:41])[CH2:2][CH2:3]1Participants
3
Sources & evidence
- ORD record
- ord-e02af6919e114743948237658c8c084f
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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