Bromide ion → 2-(4-Fluorobenzyl)-10-methoxy-4-(1-hydroxyethyl)-8-methyl-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione

HRID 934348Notes

Reaction equation

HRID 934348 reaction equation
[Br-:29].[CH2:32]([O:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH2:38][CH2:39][CH3:40].[CH3:30][Mg+:31].[CH3:42][O:43][CH2:44][CH2:45][O:46][CH3:47].[Cl:48][CH2:49][Cl:50].[ClH:41].[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][n:7]2[n:8][c:9]([CH:25]=[O:26])[c:10]3[c:11]([c:12]2=[O:13])[c:14]([O:23][CH3:24])[c:15]2[n:16]3[CH2:17][CH2:18][N:19]([CH3:22])[C:20]2=[O:21])[cH:27][cH:28]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][n:7]2[n:8][c:9]([CH:25]([OH:26])[CH3:32])[c:10]3[c:11]([c:12]2=[O:13])[c:14]([O:23][CH3:24])[c:15]2[n:16]3[CH2:17][CH2:18][N:19]([CH3:22])[C:20]2=[O:21])[cH:27][cH:28]1

Participants

8

Reactant 7

HCID 259Bromide ionHCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 80711,2-DimethoxyethaneHCID 8909Butyl etherHCID 866248002-(4-Fluorobenzyl)-8-methyl-10-methoxy-1,9-dioxo-1,2,6,7,8,9-hexahydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-4-carboxaldehydeHCID 178477777HCID 178477777, compound

Product 1

HCID 688652402-(4-Fluorobenzyl)-10-methoxy-4-(1-hydroxyethyl)-8-methyl-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione

Sources & evidence

ORD record
ord-c2bd4fcc2bb64a16bb6cb8793353c9f3
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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