Acetate → 5-Bromo-3-[5-(1-hydroxy-1-methyl-ethyl)-pyridin-2-ylamino]-1-methyl-1H-pyridin-2-one

HRID 934499Notes

Reaction equation

HRID 934499 reaction equation
[Br:12][c:13]1[c:14](=[O:21])[n:15]([CH3:20])[cH:16][c:17]([Br:19])[cH:18]1.[C:22](=[O:23])([O-:24])[O-:25].[CH3:34][CH2:35][O:36][C:37]([CH3:38])=[O:39].[Cs+:26].[Cs+:27].[NH2:1][c:2]1[cH:3][cH:4][c:5]([C:8]([CH3:9])([CH3:10])[OH:11])[cH:6][n:7]1.[O-:41][C:42]([CH3:43])=[O:44].[O-:45][C:46]([CH3:47])=[O:48].[O:28]1[CH2:29][CH2:30][O:31][CH2:32][CH2:33]1.[Pd+2:40]>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([C:8]([CH3:9])([CH3:10])[OH:11])[cH:6][n:7]1)[c:13]1[c:14](=[O:21])[n:15]([CH3:20])[cH:16][c:17]([Br:19])[cH:18]1

Participants

9

Reactant 8

HCID 175Acetate2×HCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 104967Cesium cation2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 36143503,5-Dibromo-1-methylpyridin-2(1H)-oneHCID 594737712-(6-Aminopyridin-3-yl)propan-2-ol

Product 1

HCID 594737935-Bromo-3-[5-(1-hydroxy-1-methyl-ethyl)-pyridin-2-ylamino]-1-methyl-1H-pyridin-2-one

Sources & evidence

ORD record
ord-ebfe9685bf7b4906ae87bdd93f03f3bc
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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