Hydrogen Peroxide → (3RS,4RS)-1-benzyl-4-(4-bromo-phenyl)-piperidin-3-ol

HRID 934594Notes

Reaction equation

HRID 934594 reaction equation
[BH4-:1].[CH2:27]([CH2:28][O:29][CH3:30])[O:31][CH3:32].[CH2:34]([Cl:35])[Cl:36].[CH2:3]([c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)[N:10]1[CH2:11][CH2:12][C:13]([c:16]2[cH:17][cH:18][c:19]([Br:22])[cH:20][cH:21]2)=[CH:14][CH2:15]1.[K+:24].[Na+:2].[OH-:23].[OH2:33].[OH:25][OH:26]>>[CH2:3]([c:4]1[cH:5][cH:6][cH:7][cH:8][cH:9]1)[N:10]1[CH2:11][CH2:12][CH:13]([c:16]2[cH:17][cH:18][c:19]([Br:22])[cH:20][cH:21]2)[CH:14]([OH:23])[CH2:15]1

Participants

10

Reactant 9

HCID 784Hydrogen PeroxideHCID 813Potassium CationHCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 6344DichloromethaneHCID 80711,2-DimethoxyethaneHCID 28123BorohydrideHCID 112443314-(4-Bromophenyl)-1,2,3,6-tetrahydro-1-(phenylmethyl)pyridine

Product 1

HCID 22128081(3RS,4RS)-1-benzyl-4-(4-bromo-phenyl)-piperidin-3-ol

Sources & evidence

ORD record
ord-8b5877d50e194db1a9d466ccf4786b28
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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