Methanol → 5-[8-(3,3-Dimethylpiperazin-1-yl)-6-morpholin-4-yl-9-(2,2,2-trifluoroethyl)-9H-purin-2-yl]pyrimidin-2-amine
Reaction equation
[CH2:46]([Cl:47])[Cl:48].[CH3:1][N:2]1[CH2:3][CH2:4][CH2:5][C:6]1=[O:7].[CH3:36][C:37]1([CH3:43])[NH:38][CH2:39][CH2:40][NH:41][CH2:42]1.[CH3:44][OH:45].[Cl:8][c:9]1[n:10]([CH2:31][C:32]([F:33])([F:34])[F:35])[c:11]2[n:12][c:13](-[c:24]3[cH:25][n:26][c:27]([NH2:30])[n:28][cH:29]3)[n:14][c:15]([N:18]3[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)[c:16]2[n:17]1>>[c:9]1([N:41]2[CH2:40][CH2:39][NH:38][C:37]([CH3:36])([CH3:43])[CH2:42]2)[n:10]([CH2:31][C:32]([F:33])([F:34])[F:35])[c:11]2[n:12][c:13](-[c:24]3[cH:25][n:26][c:27]([NH2:30])[n:28][cH:29]3)[n:14][c:15]([N:18]3[CH2:19][CH2:20][O:21][CH2:22][CH2:23]3)[c:16]2[n:17]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-67c759afbcbb4fc0bbe94fa56773a2c0
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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