Dichloromethane → 3-[[2-Amino-5-(3-aminopropyl)-6-methylpyrimidin-4-yl]amino]heptan-1-ol

HRID 934651Notes

Reaction equation

HRID 934651 reaction equation
[Cl:36][CH2:37][Cl:38].[F:29][C:30]([F:31])([F:32])[C:33]([OH:34])=[O:35].[NH2:1][c:2]1[n:3][c:4]([CH3:28])[c:5]([CH2:17][CH2:18][CH2:19][NH:20][C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[c:6]([NH:8][CH:9]([CH2:10][CH2:11][OH:12])[CH2:13][CH2:14][CH2:15][CH3:16])[n:7]1>>[NH2:1][c:2]1[n:3][c:4]([CH3:28])[c:5]([CH2:17][CH2:18][CH2:19][NH2:20])[c:6]([NH:8][CH:9]([CH2:10][CH2:11][OH:12])[CH2:13][CH2:14][CH2:15][CH3:16])[n:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 90950205tert-butyl N-[3-[2-amino-4-(1-hydroxyheptan-3-ylamino)-6-methylpyrimidin-5-yl]propyl]carbamate

Product 1

HCID 689536193-[[2-Amino-5-(3-aminopropyl)-6-methylpyrimidin-4-yl]amino]heptan-1-ol

Sources & evidence

ORD record
ord-ee60bdadad3947d4a34d27e57dcaee1b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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