Acetate → Methyl 3-methyl-5-phenylthiophene-2-carboxylate

HRID 934760Notes

Reaction equation

HRID 934760 reaction equation
[C:30]([O-:31])(=[O:32])[CH3:33].[C:35]([O-:36])(=[O:37])[CH3:38].[CH3:19][C:20](=[O:21])[O-:22].[CH3:24][C:25]([N:26]([CH3:27])[CH3:28])=[O:29].[CH3:8][c:9]1[c:10]([C:14](=[O:15])[O:16][CH3:17])[s:11][cH:12][cH:13]1.[I:1][c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1.[K+:18].[OH2:23].[Pd+2:34]>>[c:2]1(-[c:12]2[s:11][c:10]([C:14](=[O:15])[O:16][CH3:17])[c:9]([CH3:8])[cH:13]2)[cH:3][cH:4][cH:5][cH:6][cH:7]1

Participants

8

Reactant 7

HCID 175Acetate3×HCID 813Potassium CationHCID 962WaterHCID 11575IodobenzeneHCID 31374DimethylacetamideHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 580757Methyl 3-methylthiophene-2-carboxylate

Product 1

HCID 16124899Methyl 3-methyl-5-phenylthiophene-2-carboxylate

Sources & evidence

ORD record
ord-faf354e0d29a473baa7717a5235fb298
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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