Cyclopropanecarbonyl chloride → 1-Cyclopentyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

HRID 934870Notes

Reaction equation

[CH:18]1([C:20]([Cl:21])=[O:22])[CH2:19][CH2:25][CH2:24][CH2:23]1.[CH:1]1([CH:4]2[NH:5][CH2:6][CH2:7][c:8]3[cH:9][c:10]([O:16][CH3:17])[c:11]([O:14][CH3:15])[cH:12][c:13]32)[CH2:2][CH2:3]1.[CH:26]1([C:27]([Cl:28])=[O:29])[CH2:30][CH2:31]1>>[CH:1]1([CH:4]2[NH:5][CH2:6][CH2:7][c:8]3[cH:9][c:10]([O:16][CH3:17])[c:11]([O:14][CH3:15])[cH:12][c:13]32)[CH2:3][CH2:2][CH2:19][CH2:18]1

Participants

Reactant 3

HCID 77637Cyclopropanecarbonyl chloride

HCID 78284Cyclopentanecarbonyl chloride

HCID 196102151-Cyclopropyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 154541731-Cyclopentyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

Sources & evidence

ORD record: ord-2be89ea1a39f427584e769a102d8d672
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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