Hydrochloric Acid → (E)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime

HRID 934908Notes

Reaction equation

HRID 934908 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][N:9]=[C:10]1[CH2:11][CH2:12][c:13]2[cH:14][c:15](-[c:19]3[c:20](-[c:27]4[cH:28][cH:29][n:30][cH:31][cH:32]4)[n:21][n:22]([CH2:24][CH2:25][OH:26])[cH:23]3)[cH:16][cH:17][c:18]21.[CH3:34][OH:35].[ClH:33].[OH-:36].[OH-:38].[Pd+2:37]>>[OH:8][N:9]=[C:10]1[CH2:11][CH2:12][c:13]2[cH:14][c:15](-[c:19]3[c:20](-[c:27]4[cH:28][cH:29][n:30][cH:31][cH:32]4)[n:21][n:22]([CH2:24][CH2:25][OH:26])[cH:23]3)[cH:16][cH:17][c:18]21

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 1731223922-[4-(1-Phenylmethoxyimino-2,3-dihydroinden-5-yl)-3-pyridin-4-ylpyrazol-1-yl]ethanol

Product 1

HCID 57519545(E)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime

Sources & evidence

ORD record
ord-cf6153fab565461db537aacdf334ff18
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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