Potassium Cation → tert-Butyl 4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylate

HRID 934921Notes

Reaction equation

HRID 934921 reaction equation
[Br:7][c:8]1[cH:9][c:10]([F:28])[c:11]([NH:12][c:13]2[n:14][cH:15][n:16][c:17]3[cH:18][c:19]([OH:25])[c:20]([O:23][CH3:24])[cH:21][c:22]23)[cH:26][cH:27]1.[C:1](=[O:2])([O-:3])[O-:4].[C:29]([CH3:30])([CH3:31])([CH3:32])[O:33][C:34](=[O:35])[N:36]1[CH2:37][CH2:38][CH:39]([CH2:42][O:43][S:44]([c:45]2[cH:46][cH:47][c:48]([CH3:49])[cH:50][cH:51]2)(=[O:52])=[O:53])[CH2:40][CH2:41]1.[K+:5].[K+:6].[O:55]=[CH:56][N:57]([CH3:58])[CH3:59].[OH2:54]>>[Br:7][c:8]1[cH:9][c:10]([F:28])[c:11]([NH:12][c:13]2[n:14][cH:15][n:16][c:17]3[cH:18][c:19]([O:25][CH2:42][CH:39]4[CH2:38][CH2:37][N:36]([C:34]([O:33][C:29]([CH3:30])([CH3:31])[CH3:32])=[O:35])[CH2:41][CH2:40]4)[c:20]([O:23][CH3:24])[cH:21][c:22]23)[cH:26][cH:27]1

Participants

7

Reactant 6

HCID 813Potassium Cation2×HCID 962WaterHCID 6228DimethylformamideHCID 19660Carbonate IonHCID 106428511-(tert-Butoxycarbonyl)-4-((p-toluenesulfonyloxy)methyl)piperidineHCID 1355038524-[(4-Bromo-2-fluorophenyl)amino]-6-methoxy-7-quinazolinol

Product 1

HCID 11049999tert-Butyl 4-(((4-((4-bromo-2-fluorophenyl)amino)-6-methoxyquinazolin-7-yl)oxy)methyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-96c8632a2e224bdb9003a990387fb610
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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