Phosphorus oxychloride → 1-Chloro-6-methoxy-4-phenylisoquinoline-3-carbonitrile

HRID 935599Notes

Reaction equation

HRID 935599 reaction equation
[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6](-[c:16]3[cH:17][cH:18][cH:19][cH:20][cH:21]3)[c:7]([C:14]#[N:15])[nH:8][c:9](=[O:13])[c:10]2[cH:11][cH:12]1.[P:22]([Cl:23])([Cl:24])([Cl:25])=[O:26]>>[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:6](-[c:16]3[cH:17][cH:18][cH:19][cH:20][cH:21]3)[c:7]([C:14]#[N:15])[n:8][c:9]([Cl:24])[c:10]2[cH:11][cH:12]1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 112428516-Methoxy-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carbonitrile

Product 1

HCID 114264141-Chloro-6-methoxy-4-phenylisoquinoline-3-carbonitrile

Sources & evidence

ORD record
ord-9cb8d0038c984209af86be9202682a32
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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