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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 935900Generated: October 26, 2026

Potassium Cation → 5-Difluoromethoxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester

https://huagongshe.com/reaction/935900

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CationHCID 813—
ReactantDimethylformamideHCID 6228—
ReactantCarbonate IonHCID 19660—
ReactantAcetic acid, 2-chloro-2,2-difluoro-, ethyl esterHCID 67843—
Reactanttert-butyl 5-hydroxy-2,3-dihydro-1H-isoindole-2-carboxylateHCID 18630963—
Product5-Difluoromethoxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl esterHCID 57753212—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetValidation data from https://doi.org/10.1039/C8SC04228D
ORD IDord-f4f5e34ef0224b64bc0b796296cacf3a
Source noteValidation data from https://doi.org/10.1039/C8SC04228D